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TCV-309 chloride
CAS No. 121494-09-5
TCV-309 chloride ( TCV309 chloride | TCV 309 chloride )
产品货号. M10802 CAS No. 121494-09-5
一种高效、选择性的血小板激活因子（PAF）拮抗剂；抑制 PAF 诱导的兔和人血小板聚集，IC50 分别为 33 nM 和 55 nM；有效保护小鼠免受 PAF 和过敏性休克引起的死亡，ED50 分别为 2.1 和 2.6 ug/kg (iv)；还可逆转大鼠中 PAF 引起的低血压和内毒素引起的低血压。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1302 | 有现货 |
|
| 5MG | ￥2394 | 有现货 |
|
| 25MG | ￥8305 | 有现货 |
|
| 50MG | ￥10788 | 有现货 |
|
| 100MG | ￥15750 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TCV-309 chloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种高效、选择性的血小板激活因子（PAF）拮抗剂；抑制 PAF 诱导的兔和人血小板聚集，IC50 分别为 33 nM 和 55 nM；有效保护小鼠免受 PAF 和过敏性休克引起的死亡，ED50 分别为 2.1 和 2.6 ug/kg (iv)；还可逆转大鼠中 PAF 引起的低血压和内毒素引起的低血压。
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产品描述A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively; potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 of 2.1 and 2.6 ug/kg (i.v.), respectively; also reverses PAF-induced hypotension and endotoxin-induced hypotension in rats.Coagulation DisorderPhase 2 Discontinued.
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体外实验——
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体内实验In rats, TCV-309 selectively inhibits the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 most potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively. TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively.
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同义词TCV309 chloride | TCV 309 chloride
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Cardiovascular Disease
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适应症Coagulation Disorder
化学信息
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CAS Number121494-09-5
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分子量629.9724
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分子式C30H34BrClN4O4
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 6.3 mg/mL
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SMILESCCC[N+]1=CC(=CC(=C1)Br)C(=O)N(CCC(=O)NCCOC(=O)N2CCC3=CC=CC=C3C2)C4=CC=CC=C4.[Cl-]
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化学全称Pyridinium, 3-bromo-5-[[[3-[[2-[[(3,4-dihydro-2(1H)-isoquinolinyl)carbonyl]oxy]ethyl]amino]-3-oxopropyl]phenylamino]carbonyl]-1-propyl-, chloride (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Terashita Z, et al. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55.
2. Motoyama N, et al. Eur J Pain. 2013 Sep;17(8):1156-67.
3. Kuipers B, et al. J Immunol. 1994 Mar 1;152(5):2438-46.
产品手册
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