Rapanone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Rapanone 是一种天然苯醌，是人类滑膜 PLA2 的有效且选择性抑制剂。

Rapanone is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

Rapanone (10-40 μM; 24 h) inhibits the cell viability, with IC50s of 35.58 μM and 27.89 μM for primary rats hepatocytes and HepG2 cells, respectively.Rapanone (10-40 μM; 24 h) induces a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization in HepG2 cells.Rapanone inhibits electron transport at Complex III and promotes mitochondrial dysfunction.

Rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice.

2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione | 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone

Metabolic Enzyme/Protease

Phospholipase

PLA2

——

——

573-40-0

322.44

C19H30O4

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (77.53 mM)

CCCCCCCCCCCCCC(C(C(O)=CC1=O)=O)=C1O

——

(-20℃)

With Ice Pack

≥ 2 years