Pinoresinol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

松脂醇具有抗炎、保肝和杀菌活性，可以保护软脑膜微循环免受再灌注损伤，增加一氧化氮释放并减少氧化应激，保持软脑膜血流分布。

Pinoresinol has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric oxide release and to reduce oxidative stress preserving pial blood flow distribution; it may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C.elegans. Pinoresinol causes an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels, inhibits NF-kappaB and activating protein 1 (AP-1).

Pinoresinol facilitated death-inducing signaling complex formation to trigger a caspase-8-dependent apoptotic cascade activation in TRAIL-resistant glioblastoma cells.

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(+)-Pinoresinol

Angiogenesis

CDK

CDK|NF-κB|p53

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487-36-5

358.4

C20H22O6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (279.03 mM)

COc(cc([C@H]1OC[C@@H]2[C@@H](c(cc3)cc(OC)c3O)OC[C@H]12)cc1)c1O

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(-20℃)

With Ice Pack

≥ 2 years