(Z)-Guggulsterone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(Z)-Guggulsterone 通过引起细胞凋亡来抑制人类前列腺癌细胞的生长。 Z-guggulsterone 通过抑制 VEGF-VEGF-R2-Akt 信号轴来抑制血管生成。

(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.

Western Blot Analysis Cell Line:Vascular endothelial growth factor (VEGF)Concentration:10, 20 μM Incubation Time:24 or 48 hours Result:Caused a decrease in the level of VEGF-R2 protein in HUVEC.

Animal Model:Male nude mice(5–6 weeks old) s.c. implanted with DU145 cell-containing Matrigel plugs Dosage:1 mg Administration:Oral; 5 times/week Result:Resulted in a statistically significantly decrease in tumor volume and wet tumor weight.

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Cytoskeleton/Cell Adhesion Molecules

Akt

Akt|VEGF-R2

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39025-23-5

312.45

C21H28O2

>98% (HPLC)

DMSO:10 mg/mL?(32.01 mM;?ultrasonic and warming and heat to 60°C)

C/C=C/1\C(=O)C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C

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(-20℃)

With Ice Pack

≥ 2 years