Arnicolide D

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Arnicolide D 是一种倍半萜内酯。 Arnicolide D 从 Centipeda minima 中分离出来。 Arnicolide D 调节细胞周期，激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。 Arnicolide D 以浓度和时间依赖性方式抑制鼻咽癌 (NPC) 细胞活力。 Arnicolide D 对人结肠癌 HT-29 细胞系具有很强的细胞毒活性。

Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D exerts strong cytotoxic activity on the human colon carcinoma HT-29 cell line.(In Vitro):In this study, we found that two sesquiterpene lactones, isobutyroylplenolin and Arnicolide D, from Centipeda minima L. (Compositae) exerted stronger cytotoxic activity than cisplatin on the human colon carcinoma HT-29 cell line. Furthermore, the cytotoxicity of these two compounds on normal cells was weaker than that of cisplatin.

——

——

——

Cytoskeleton/Cell Adhesion Molecules

Akt

Akt

——

——

34532-68-8

332.396

C19H24O5

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (75.21 mM)

C[C@H]1[C@@H]2[C@@H](C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@H]2OC(=O)C(C)=C)OC1=O

——

(-20℃)

With Ice Pack

≥ 2 years