AH 6809

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AH 6809 是 EP 和 DP 受体的拮抗剂（对克隆的人 EP1、EP2、EP3-III 和 DP 受体的 Kis 分别为 1217、1150、1597 和 1415 nM）。

AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively). AH 6809 has a Ki of 350 nM for mouse EP2 receptor.

AH 6809 (1?μM; 30 min) inhibits T. serrulatus venom (TsV)-induced and PGE2-amplified IL-1β and cAMP production in macrophages.AH 6809 (30-300 μM) antagonizes the anti-aggregatory activity of PGD2 in whole blood, with an apparent pA2 of 5.35.

AH 6809 (5 mg/kg; i.p.) decreases TsV-induced mortality, PGE2 and IL-1β production and neutrophil infiltration in the lungs of mice.

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GPCR/G Protein

Prostaglandin Receptor

DP|EP1|EP2|EP3

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33458-93-4

298.29

C17H14O5

>98% (HPLC)

DMSO:25 mg/mL (83.81 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)

CC(C)Oc(cc1)cc(Oc(cc2)c3cc2C(O)=O)c1C3=O

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(-20℃)

With Ice Pack

≥ 2 years