Travoprost

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

曲伏前列素用于治疗青光眼和高眼压症，是一种有效的选择性 FP 前列腺素受体激动剂。

Travoprost is used to treat glaucoma and ocular hypertensionis a potent and selective FP prostaglandin receptor agonist.(In Vitro):Travoprost has sub-micromolar affinity for the DP, EP1, EP3, EP4, IP, and TP receptors.(In Vivo):Travoprost produces a lower incidence of ocular irritation than PGF20 isopropyl ester at a dose of 1 μg in the New Zealand albino (NZA) rabbit. Topical ocular application of Travoprost produces a marked miotic effect in cats following doses of 0.01, 0.03 and 0.1 μg. In the ocular hypertensive monkey, b.i.d. application of 0.1 and 0.3 μg of travoprost afforded peak reduction in intraocular pressure (IOP) of 22.7% and 28.6%, respectively. Topical application of travoprost was well tolerated in rabbits, cats and monkeys, causing no ocular irritation or discomfort at doses up to 1 μg.

Travoprost has sub-micromolar affinity for the DP, EP1, EP3, EP4, IP, and TP receptors.

Travoprost produces a lower incidence of ocular irritation than PGF20 isopropyl ester at a dose of 1 μg in the New Zealand albino (NZA) rabbit. Topical ocular application of Travoprost produces a marked miotic effect in cats following doses of 0.01, 0.03 and 0.1 μg. In the ocular hypertensive monkey, b.i.d. application of 0.1 and 0.3 μg of travoprost afforded peak reduction in intraocular pressure (IOP) of 22.7% and 28.6%, respectively. Topical application of travoprost was well tolerated in rabbits, cats and monkeys, causing no ocular irritation or discomfort at doses up to 1 μg.

Fluprostenol isopropyl ester | AL6221 | Flu-Ipr

GPCR/G Protein

Prostaglandin Receptor

Prostaglandin Receptor

Others

open-angle glaucoma or ocular hypertension

157283-68-6

500.55

C26H35F3O6

>98% (HPLC)

DMSO:41.67 mg/mL (83.25 mM)

CC(C)OC(=O)CCC\C=C/CC1C(O)CC(O)C1\C=C\C(O)COc1cccc(c1)C(F)(F)F

propan-2-yl (Z)-7-[(1R2R3R5S)-35-dihydroxy-2-[(E3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate

(-20℃)

With Ice Pack

≥ 2 years