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NRX-252262
CAS No. 2438637-61-5
NRX-252262 ( —— )
产品货号. M24123 CAS No. 2438637-61-5
NRX-252262 是 β-连环蛋白及其同源 E3 连接酶 SCFβ-TrCP 之间相互作用的有效增强剂，可诱导突变型 β-连环蛋白降解 (EC50:3.8 nM)
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2204 | 有现货 |
|
| 10MG | ￥3306 | 有现货 |
|
| 25MG | ￥5375 | 有现货 |
|
| 50MG | ￥7282 | 有现货 |
|
| 100MG | ￥9450 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥2641 | 有现货 |
|
生物学信息
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产品名称NRX-252262
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NRX-252262 是 β-连环蛋白及其同源 E3 连接酶 SCFβ-TrCP 之间相互作用的有效增强剂，可诱导突变型 β-连环蛋白降解 (EC50:3.8 nM)
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产品描述NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM).
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体外实验NRX-252262 (35?μM) causes S33E/S37A mutant β-catenin degradation in cells.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体SCF(β-TrCP)-E3 ligase
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研究领域——
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适应症——
化学信息
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CAS Number2438637-61-5
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分子量545.36
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分子式C23H17Cl2F3N2O4S
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纯度>98% (HPLC)
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溶解度DMSO:8 mg/mL?(14.67 mM;?Need ultrasonic)
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SMILESO=C1C(C(N2CC3=C(C=C(OC)C(OC)=C3)C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.
产品手册
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