Trimethoprim lactate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Trimethoprim lactate 是一种抑菌抗生素 (antibiotic)，也是一种具有口服活性的二氢叶酸还原酶 (dihydrofolate reductase) 抑制剂。Trimethoprim lactate 对多种革兰氏阳性 (Gram-positive) 和革兰氏阴性需氧细菌 (Gram-negative aerobic bacteria) 具有活性。Trimethoprim lactate 可用于尿路感染，志贺氏菌病和肺孢子菌肺炎的研究。Trimethoprim lactate 与锌联合使用可抑制甲型流感病毒 (Influenza A virus) 对鸡胚的感染。

Trimethoprim lactate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim lactate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc.

Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF).Trimethoprim (3 μg/mL; 1 h) induces protein aggregation and main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim sulfate presence leads to protein misfolding.Trimethoprim (1.5-3 μg/mL; 1 h) causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps in E. coli cells exposed to folate and heat stress.

Trimethoprim (10 mg/kg; i.v.; once every 12 h; 3 d) shows antibacterial activity against H. influenzae, S. pneumoniae, E. coli and N. meningitidis in infected mice.Trimethoprim can be connected with the thiomaltose (TM-TMP) and shows stability with a half-life of about 1 hour in complete serum, and has an MIC value around 1 μM against E. coli.Trimethoprim (10 mg/mL; 0.5 mL; inject with Trimethoprim-Zn combined suspension) decreases the virus titer and increases the survival rate of chicken embryo.Animal Model:Female C3H/HeOuJ mice (transurethrally infected with a 50 μL suspension containing 1-2×107 CFU of E. coli under 3% isoflurane)Dosage:10 mg/kg Administration:i.v.; once every 12 h; for 3 d Result:Showed antibacterial activity against H. influenzae, S. pneumoniae, E. coli and N. meningitidis with CD50s of 150 mg/kg, 335 mg/kg, 27.5 mg/kg and 8.4 mg/kg, respectively in infected mice.Animal Model:Fertilized eggs (injected H3N2 virus into amniotic and allantoic space at day 8) Dosage:10 mg/mL; 0.5 mL Administration:The Trimethoprim-Zn combined suspension was injected into the air sac; single dosage Result:Decreased the virus titer and increased the survival rate of chicken embryo.The survival rate peaked at ratio about 0.18 (Zn/Trimethoprim).

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23256-42-0

380.401

C17H24N4O6

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (657.20 mM; 超声助溶 ) H2O 中的溶解度 : 16.67 mg/mL (43.82 mM; 超声助溶)

C[C@H](O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

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(-20℃)

With Ice Pack

≥ 2 years