PD 089828

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PD 089828 是受体酪氨酸激酶 FGFR1、PDGFRβ 和 EGFR 的竞争性抑制剂（IC50 分别 = 0.15、1.76 和 5.47 μM），也是非受体酪氨酸激酶 c-Src 的非竞争性抑制剂（IC50 = 0.18 μM）

PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)

PD-089828 (0.5-20 μM; 2 hours) inhibits PDGFR autophosphorylation with an IC50 of 0.82 μM.PD-089828 (1-50 μM; 2 hours) inhibits EGFR autophosphorylation with an IC50 value of 10.9 μM.In A121(p) cells, PD 089828 potently inhibits the phosphorylation of FGFR-1 with an IC50 value of 0.63 μM.PD-089828 (10 μM; 8 days) produces a concentration-related inhibition of serum-stimulated cell growth with an IC50 value of 1.8 μM.PD-089828 inhibits increases in DNA synthesis stimulated by all three growth factors, with IC50 values of 0.8 for PDGF-, 1.7 for EGF- and 0.48 μM for bFGF-induced mitogenesis. Cell Proliferation Assay Cell Line:Vascular smooth muscle cells (serum-stimulated growth)Concentration:10 μM Incubation Time:8 consecutive days Result:Produced a concentration-related inhibition of serum-stimulated cell growth with an IC50 value of 1.8 μM.Western Blot Analysis Cell Line:Vascular smooth muscle cells (stimulated with PDGF-BB 30 ng/ml) Concentration:0.5-20 μM Incubation Time:2 hours Result:Inhibited PDGFR autophosphorylation with an IC50 of 0.82 μM.

——

PD-089828 | PD089828

Angiogenesis

EGFR

EGFR|FGFR1|PDGFRβ

——

——

179343-17-0

405.28

C18H18Cl2N6O

>98% (HPLC)

DMSO:2.5 mM

CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl

——

(-20℃)

With Ice Pack

≥ 2 years