5-Iodotubercidin ( NSC 113939 | 5-ITu )

产品货号. M17451 CAS No. 24386-93-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

5-Iodotubercidin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

5-Iodotubercidin 是一种有效的腺苷激酶抑制剂，IC50 为 26 nM。它抑制核苷转运蛋白、CK1、胰岛素受体酪氨酸激酶、磷酸化酶激酶、PKA、CK2 和 PKC。
产品描述

5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.
体外实验

5-Iodotubercidin (NSC 113939) inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC, and the IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively.5-Iodotubercidin (20 μM) causes an important decrease in ATP concentration, and a concomitant smaller increase in AMP concentration. 5-Iodotubercidin decreases the activity of ACC and the rates of synthesis of fatty acids and cholesterol. In line with the iodotubercidin-mediated inhibition of ACC, 5-iodotubercidin induces a marked decrease in the intracellular concentration of malonyl-CoA.
体内实验

5-Iodotubercidin (1 mL/kg, i.p.) is in agreement with activity observed against bicuculline-induced seizures following local administration of the AKI into the prepiriform cortex.
同义词

NSC 113939 | 5-ITu
通路

Angiogenesis
靶点

EGFR
受体

adenosine kinase
研究领域

Cancer
适应症

——

1.Zhang X,etal.Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential. PLoS One. 2013 May 7;8(5):e62527.

计算器

产品手册

关联产品

AST-1306

AST-1306是一种新型不可逆EGFR和ErbB2抑制剂，IC50分别为0.5 nM和3 nM，对EGFR T790M/L858R突变也有效。
Labuxtinib

Labuxtinib 是 c-kit 酪氨酸激酶抑制剂。
PAT-505 B

PAT-505 是一种有效，选择性的，非竞争性的可口服的 autotaxin 抑制剂，在 Hep3B 中，抑制 autotaxin 的活性，IC50 值为 2 nM，在人血液和小鼠血浆中，IC50 值分别为 9.7 nM 和 62 nM。