5-Iodotubercidin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

5-Iodotubercidin 是一种有效的腺苷激酶抑制剂，IC50 为 26 nM。它抑制核苷转运蛋白、CK1、胰岛素受体酪氨酸激酶、磷酸化酶激酶、PKA、CK2 和 PKC。

5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.

5-Iodotubercidin (NSC 113939) inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC, and the IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively.5-Iodotubercidin (20 μM) causes an important decrease in ATP concentration, and a concomitant smaller increase in AMP concentration. 5-Iodotubercidin decreases the activity of ACC and the rates of synthesis of fatty acids and cholesterol. In line with the iodotubercidin-mediated inhibition of ACC, 5-iodotubercidin induces a marked decrease in the intracellular concentration of malonyl-CoA.

5-Iodotubercidin (1 mL/kg, i.p.) is in agreement with activity observed against bicuculline-induced seizures following local administration of the AKI into the prepiriform cortex.

NSC 113939 | 5-ITu

Angiogenesis

EGFR

adenosine kinase

Cancer

——

24386-93-4

392.15

C11H13IN4O4

>98% (HPLC)

DMSO : ≥ 49 mg/mL; 124.95 mM

Nc1ncnc2c1c(I)cn2[C@@H]1O[C@H](CO)[C@H](O)C1O

——

(-20℃)

With Ice Pack

≥ 2 years