AG-636

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AG-636 是一种有效、可逆、选择性、口服活性的 DHODH 抑制剂（IC50 为 17 nM）。它具有很强的抗癌作用。

AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.

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Animal Model:Transgenic female 6-8-week-old CB17/Icr-Prkdcscid/IcrIcoCrl (CB17 SCID) mice injected with OCILY19 cells Dosage:10 mg/kg, 30 mg/kg, or 100 mg/kg Administration:Oral gavage; twice daily; for 14 days Result:Resulted in robust tumor growth inhibition in xenograft lymphoma tumor models.

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Metabolic Enzyme/Protease

Dehydrogenase

DHODH|DNA/RNA Synthesis

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1623416-31-8

343.38

C21H17N3O2

>98% (HPLC)

DMSO:31.25 mg/mL (91.01 mM; Need ultrasonic)

O=C(C1=C(N(C)N=N2)C2=CC(C3=CC=C(C4=CC=CC=C4C)C=C3)=C1)O

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(-20℃)

With Ice Pack

≥ 2 years