C29

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

C29 是一种新型抑制剂，可抑制人类 HEK-TLR2 和 THP-1 细胞中由合成 TLR2 激动剂和细菌 TLR2 激动剂诱导的 TLR2/1 和 TLR2/6 信号传导，但仅抑制小鼠巨噬细胞中的 TLR2/1 信号传导。

TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.(In Vitro):C29 (10 or 50 μΜ; 1 hour) blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 (50-200 μM; 1 hour) inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation in THP-1 cells.C29 (25 or 50 μΜ; 1 hour) reduces P3C-induced but not P2C-induced TNF-α mRNA and IL-12 p40 protein significantly in primary murine macrophages.C29 (50 μΜ; 1 hour) blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 cells and murine macrophages.

Western Blot Analysis Cell Line:THP-1 cells Concentration:150 μM Incubation Time:1 hours Result:Diminished the interaction between endogenous TLR2 and myeloid differentiation primary response gene 88 (MyD88) at 15 and 30 min poststimulation with P3C.Western Blot Analysis Cell Line:Murine peritoneal macrophages Concentration:50 μM Incubation Time:1 hours Result:Blocked robust MAPK activation at 30 min and reduced NF-κB activation from 5 to 30 min. Prevented P3C-induced degradation of IκBα at 15 and 30 min.

——

TLR2-IN-C29 | TLR2 IN C29 | TLR2INC29 | TLR2-inhibitor-C29

Metabolic Enzyme/Protease

Dehydrogenase

TLR2/1| TLR2/6

Others-Field

——

363600-92-4

285.3

C16H15NO4

>98% (HPLC)

DMSO : ≥ 30 mg/mL; 105.16 mM

COc1cccc(\C=N\c2cccc(C(O)=O)c2C)c1O

3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid

(-20℃)

With Ice Pack

≥ 2 years