TX1-85-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TX1-85-1 诱导 Her3 蛋白部分降解并减弱 Her3 依赖性信号传导。

TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.

TX1-85-1 possesses an anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively.

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Angiogenesis

EGFR

ErbB3

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1603845-32-4

580.68

C32H36N8O3

>98% (HPLC)

DMSO:3.85 mg/mL (6.63 mM; Need ultrasonic)

CC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O

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(-20℃)

With Ice Pack

≥ 2 years