Cloperastine fendizoate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cloperastine fendizoate 抑制 hERG K+ 电流，IC50 为 27 nM，这种作用具有浓度依赖性。

Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.

Cloperastine inhibits the hERG K+ currents in a concentrationdependent manner with IC50 value of 27±3 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.

In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.

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Angiogenesis

EGFR

EGFR

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85187-37-7

648.19

C40H38ClNO5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 10 mg/mL (15.43 mM; 超声助溶 )

Clc1ccc(cc1)C(OCCN1CCCCC1)c1ccccc1.OC(=O)c1ccccc1C(=O)c1ccc(O)c(c1)-c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years