SR-3677

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SR-3677 是一种有效且特异性的 ROCK2 抑制剂 (IC50: 3 nM)。

SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).(In Vitro):SR-3677 has an IC50 of ~3 nM in enzyme and cell based assays and has an off-target hit rate of 1.4% against 353 kinases, and inhibits only 3 out of 70 nonkinase enzymes and receptors. The IC50 value of SR-3677 for ROCK-I is 56±12 nM. The hydrophobic interaction of the benzodioxane phenyl ring with the hydrophobic surface of the pocket is the dominating factor that contributes to the high potency of SR-3677.(In Vivo): Pharmacology studies shows that SR-3677 is efficacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation. Continuous exposure of 25 μM SR-3677 increases the outflow facility by 60% at 1 h perfusion, increasing to 70–80% for the 2–5 h time points.

——

——

——

Autophagy

Autophagy

Autophagy|ROCK1|ROCK2

——

——

1072959-67-1

408.45

C22H24N4O4

>98% (HPLC)

DMSO:40 mg/mL (97.93 mM)

CN(C)CCOC1=C(NC(C2OC(C=CC=C3)=C3OC2)=O)C=CC(C4=CNN=C4)=C1

——

(-20℃)

With Ice Pack

≥ 2 years