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ROC-325
CAS No. 1859141-26-6
ROC-325 ( ROC 325 | ROC325 )
产品货号. M12869 CAS No. 1859141-26-6
ROC-325 (ROC 325, ROC325) 是一种新型、口服的溶酶体介导的自噬抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥323 | 有现货 |
|
| 5MG | ￥470 | 有现货 |
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| 10MG | ￥747 | 有现货 |
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| 25MG | ￥1460 | 有现货 |
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| 50MG | ￥2167 | 有现货 |
|
| 100MG | ￥3006 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ROC-325
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ROC-325 (ROC 325, ROC325) 是一种新型、口服的溶酶体介导的自噬抑制剂。
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产品描述ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy; exhibits superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in different cancer cell lines, including accumulation of autophagosomes with undegraded cargo, lysosomal deacidification, p62 stabilization, and disruption of autophagic flux; antagonizes RCC growth and survival in an ATG5/7-dependent manner, induces apoptosis and exhibited favorable selectivity; significantly more effective at inhibiting tumor progression than HCQ, and inhibited autophagy in vivo.
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体外实验——
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体内实验——
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同义词ROC 325 | ROC325
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通路Autophagy
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靶点Autophagy
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受体Autophagy
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研究领域Cancer
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适应症——
化学信息
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CAS Number1859141-26-6
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分子量503.061
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分子式C28H27ClN4OS
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纯度>98% (HPLC)
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溶解度DMSO : 32 mg/mL 63.61 mM; H2O : < 0.1 mg/mL
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SMILESO=C1C2=C(C(C)=CC=C2NCCN(C)CCNC3=C(C=CC(Cl)=C4)C4=NC=C3)SC5=CC=CC=C51
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化学全称1-((2-((2-((7-chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Carew JS, et al. Clin Cancer Res. 2017 Jun 1;23(11):2869-2879.
2. Carew JS, et al. Autophagy. 2017 Apr 3;13(4):765-766.
