Benidipine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Benidipine HCl 是 Benidipine 的盐酸盐形式，是一种二氢吡啶钙通道阻滞剂。

Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.

Western Blot Analysis Cell Line:Murine PBMCs Concentration:1 μM Incubation Time:7 days Result:Increased the expression of phosphorylated Akt on serine-473.Cell Proliferation Assay Cell Line:Mesangial cells Concentration:0.1-10 μM Incubation Time:48 h Result:Inhibited the progression of the cell cycle in a dose-dependent manner.

Animal Model:MI/R rabbits model Dosage: 3-10 μg/kg Administration:i.v.Result:Caused a significant decrease in HR ( heart rate), MABP (mean arterial blood pressure), and PRI (pressure-rate index) at 10 μg/kg.Decreased apoptotic positive cells to 7.4% at 3 μg/kg.Animal Model:Renovascular hypertensive rats (RHR) model Dosage:5 mg/kg Administration:i.v.Result:Decreased the blood pressure and coronary vascular resistance index.Increased nitrite production and eNOS mRNA expression and the coronary flow at rest, the capillary density.Animal Model:Rat heart model Dosage:1-10 mg/kg Administration:p.o.Result:Increased the post-ischemic recovery of LVDP and LV dP/dt max (LVDP: 87.5±10.1 vs 64.6±11.9%;LV dP/dt max: 97.8±10.4 vs 70.2±15.7%) at 3 mg/kg.

(±)-Benidipine | KW-3049

Angiogenesis

EGFR

EGFR (L861Q)| c-Src| c-Yes| Lck| Lyn

Cardiovascular Disease

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91599-74-5

542.03

C27H32ClN5O5

>98% (HPLC)

DMSO: 8 mg/mL (14.75 mM)

CC1=C([C@H](C(=C(N1)C)C(=O)O[C@@H]2CCCN(C2)CC3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl

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(-20℃)

With Ice Pack

≥ 2 years