CU-CPT22

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CU-CPT22 是第一个针对 Toll 样受体 TLR1 和 TLR2 之间复合物的探针。 CU-CPT22 结合在 TLR1 和 TLR2 的界面上 (IC50 = 0.58 μM)。它与合成三酰化脂蛋白 (Pam3CSK4) 竞争与 TLR1/2 的结合（Ki：0.41 μM）。

CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2.?CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM).?It competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 (Ki: 0.41 μM).?A novel compound (CU-CPT22) that can compete with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with high inhibitory activity and specificity.CU-CPT22 is a toll-like inhibitor of receptor 1 and 2 (TLR1/2) ( IC50: 0.58±0.09 μM).?CU-CPT22 is found to have no significant cytotoxicity at various concentrations up to 100 μM in RAW 264.7 cells.?It is showed that CU-CPT22 is able to compete with Pam3CSK4 for binding to TLR1/2 (Ki: 0.41±0.07 μM).?Which is consistent with its potency observed in the whole cell assay.?Increasing the concentration of CU-CPT22 to 6 μM decreases the anisotropy to background levels.?It is found that CU-CPT22 inhibits TLR1/2 signaling without affecting other TLRs, showing it is highly selective in intact cells.??The result shows that CU-CPT22 can inhibit about 60% of TNF-αand 95% of IL-1β at 8 μM.

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Immunology/Inflammation

TLR

TLR2/1

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1416324-85-0

362.37

C19H22O7

>98% (HPLC)

DMSO:125 mg/mL (344.95 mM)

O=C(C(C=C1O)=CC2=CC(OC)=C(O)C(O)=C2C1=O)OCCCCCC

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(-20℃)

With Ice Pack

≥ 2 years