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Melittin TFA(20449-79-0(free base))
CAS No. ——
Melittin TFA(20449-79-0(free base)) ( —— )
产品货号. M22789 CAS No. ——
蜂毒肽TFA是一种含有26个氨基酸残基的小蛋白质，是蜂毒的主要有毒成分。 Melittin 是一种 PLA2 激活剂，可刺激低分子量 PLA2 的活性，但不会增加高分子量 PLA2 的活性。Melittin 是一种来自蜂毒的免疫相关 PLA2 刺激肽，可增加高分子量 PLA2 的活性酶。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥4384 | 有现货 |
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| 10MG | ￥7322 | 有现货 |
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| 50MG | 获取报价 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Melittin TFA(20449-79-0(free base))
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述蜂毒肽TFA是一种含有26个氨基酸残基的小蛋白质，是蜂毒的主要有毒成分。 Melittin 是一种 PLA2 激活剂，可刺激低分子量 PLA2 的活性，但不会增加高分子量 PLA2 的活性。Melittin 是一种来自蜂毒的免疫相关 PLA2 刺激肽，可增加高分子量 PLA2 的活性酶。
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产品描述Melittin TFA is a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.Melittin, an immunologically related PLA2 stimulating peptide from bee venom, increases the activity of the high molecular weight enzyme. Melittin is a cytotoxic peptide from bee venom. Melittin exhibits toxicity against both A2780CR and A2780 cells, with IC50 values of 4.5 and 6.8 μg/mL, respectively. Melittin has natural anti-bacterial, anti-viral, and anti-inflammatory properties. It has also been shown to have diverse anticancer effects in several different cancer cell lines including those of gastric, breast, ovarian, liver, prostate, cervical, and lung origins. The mechanisms by which Melittin, an amphipathic haemolytic peptide, exerts its potential anticancer effects include inhibition of cell proliferation, induction of apoptosis, and direct necrosis. Melittin can also prevent EGF-induced cell invasion through its inhibition of the PI3K/Akt/mTOR signaling pathway, but this is primarily related to breast cancer cells.
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体外实验——
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体内实验——
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Phospholipase
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受体PLA2
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量2846.46
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分子式C131H229N39O31
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纯度>98% (HPLC)
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溶解度——
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SMILESOC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)CN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Steiner MR, et al. Responses of purified phospholipases A2 to phospholipase A2 activating protein (PLAP) and Melittin. Biochim Biophys Acta. 1993 Feb 10;1166(1):124-30.
