U73122

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

U73122 是一种有效的磷脂酶 C (PLC) 抑制剂，可减少激动剂诱导的血小板和 PMN 中 Ca2+ 的增加。

U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN.(In Vitro):U-73122 potently inhibits receptor-coupled activation of PLC in membranes isolated from PMNs. U-73122 inhibits N-formyl-methionyl-leucyl-phenylalanine-induced aggregation of human polymorphonuclear neutrophils (PMN) and the associated production of IP3 and diacyglycerol. U-73122 markedly inhibits inositol phosphate release elicited by either oxotremorine-M or guanosine-5'-O-(3-thiotriphosphate) than that induced by added Ca2+ in digitonin-permeabilized cells. (In Vivo):U73122 significantly attenuates TNF-α mRNA expression, has no effect on sham animals, but significantly increases heart work and rate of contraction and relaxation without affecting heart rate in endotoxemic mice. U73122 (400 nM/μL) significantly reduces total lordosis durations, compared to vehicle infusions to the VTA, of oestradiol and progesterone-primed hamsters. VTA infusions of U73122 do not alter motor behaviour of hamsters in the activity monitor, but there is a significant effect of muscimol to decrease total number of beam breaks compared to hamsters administered SKF38393.

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Metabolic Enzyme/Protease

Phospholipase

PLC

Inflammation/Immunology

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112648-68-7

464.64

C29H40N2O3

>98% (HPLC)

DMF: 24 mg/mL warmed (51.65 mM)

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC

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(-20℃)

With Ice Pack

≥ 2 years