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GR 125743
CAS No. 148547-33-5
GR 125743 ( —— )
产品货号. M22737 CAS No. 148547-33-5
GR 125743 是一种新型 5-HT1B/1D 受体拮抗剂。GR-125743 是一种新型放射性标记化合物衍生物，对血清素人 (h5-HT1D) 和人 (h5-HT1B) 受体表现出选择性拮抗特性。该化合物的特点是能够标记克隆的 h5-HT1D 和 h5-HT1B 受体。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥440 | 有现货 |
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| 5MG | ￥738 | 有现货 |
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| 10MG | ￥1121 | 有现货 |
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| 25MG | ￥2223 | 有现货 |
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| 50MG | ￥3329 | 有现货 |
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| 100MG | ￥4662 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥867 | 有现货 |
|
生物学信息
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产品名称GR 125743
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GR 125743 是一种新型 5-HT1B/1D 受体拮抗剂。GR-125743 是一种新型放射性标记化合物衍生物，对血清素人 (h5-HT1D) 和人 (h5-HT1B) 受体表现出选择性拮抗特性。该化合物的特点是能够标记克隆的 h5-HT1D 和 h5-HT1B 受体。
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产品描述GR 125743 is a novel antagonist of 5-HT1B/1D receptor.GR-125743, a new radiolabelled derivative of a compound that exhibits selective antagonistic properties with respect to the serotonin human (h5-HT1D) and human (h5-HT1B) receptors.?The compound has been characterized for its ability to label the cloned h5-HT1D and h5-HT1B receptors.?
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体外实验GR 125743 has a Kd of 0.61 nM for h5-HT1B.
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体内实验GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig. Animal Model:Male Dunkin Hartley guinea-pigs (350-450 g)Dosage:0.3 mg/kg Administration:Intraperitoneal injection Result:Produced significant transient increases in extracellular 5-HT.
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同义词——
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT1B/1D
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研究领域——
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适应症——
化学信息
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CAS Number148547-33-5
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分子量416.53
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分子式C25H28N4O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (240.08 mM)
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SMILESCOc1ccc(NC(=O)c2ccc(c(C)c2)-c2ccncc2)cc1N1CCN(C)CC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. T Doménech, J Beleta, J M Palacios,et al.Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist.Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):328-34.
