Ro 60-0175

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ro 60-0175 是一种有效的选择性 5-HT2C 受体激动剂。

Ro 60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively; induces hypolocomotion in rats at doses greater than 0.5 mg/kg s.c.; (0.3 and 1 mg/kg s.c.) simultaneously reduces both unpunished and punished lever pressing, a profile consistent with sedation, induces sedative-like responses via 5-HT(2C) receptor activation in vivo.

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Animal Model:Adult male Sprague-Dawley rats (280-320 g)Dosage:1 mg/kg Administration:s.c.Result:Preserved the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reached their break-points earlier.Animal Model:Adult male Sprague-Dawley rats (280-320 g)Dosage:0.5?mg/kg (SB242084), 1?mg/kg (Ro60-0175)Administration:s.c. (Ro60-0175), i.p. (SB242084)Result:Reduced responding for cocaine and effect was reversed by SB242084.Animal Model:Adult male Sprague-Dawley rats (280-320 g)Dosage:0.3, 1, and?3 mg/kg (Ro60-0175), 1?mg/kg (yohimbine) Administration:s.c. (Ro60-0175), i.p. (yohimbine)Result:Showed yohimbine treatment alone increased responding relative to vehicle injection, and the response was attenuated dose dependently by Ro60-0175.Animal Model:Adult male Sprague-Dawley rats (280-320 g) Dosage:0.5 mg/kg (SB242084), 1?mg/kg (Ro60-0175), 1?mg/kg (yohimbine) Administration:s.c. (Ro60-0175), i.p. (yohimbine), i.p. (SB242084) Result:Ro60-0175 reduced responding and that this effect was prevented by SB242084 pretreatment.

Ro 600175

Endocrinology/Hormones

5-HT Receptor

5-HT Receptor

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169675-08-5

226.679

C11H12ClFN2

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (551.44 mM)

CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O

1H-Indole-1-ethanamine, 6-chloro-5-fluoro-α-methyl-, (S)-

(-20℃)

With Ice Pack

≥ 2 years