NSC-60339
CAS No. 70-09-7
NSC-60339 ( —— )
产品货号. M22105 CAS No. 70-09-7
NSC-60339 是一种外排泵抑制剂,也是 AcrAB-TolC 的底物,是一种多元对苯二甲酸衍生物,被研究作为潜在的癌症化疗剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ¥1511 | 有现货 |
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| 10MG | ¥2214 | 有现货 |
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| 25MG | ¥3432 | 有现货 |
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| 50MG | ¥4622 | 有现货 |
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| 100MG | ¥5877 | 有现货 |
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| 200MG | ¥7911 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NSC-60339
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述NSC-60339 是一种外排泵抑制剂,也是 AcrAB-TolC 的底物,是一种多元对苯二甲酸衍生物,被研究作为潜在的癌症化疗剂。
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产品描述NSC-60339 is an inhibitor of efflux pump, and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent.
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体外实验NSC 60339 has been correlated with the sensitivity, resistance, or cross-resistance of 7 tumor lines to phthalanilide treatment in vivo. The sensitive tumors (L1210, L1210/MTX, L1210/ara-C, and P815) rapidly takes up the drug and retained it primarily as lipid-bound drug for the 24-hr experimental period. The resistant tumor, L1210/NSC 60339, and 2 cross-resistant tumors, P388/VCR and P815/VLB, took up as much drug as the sensitive tumors did by 0.5 hr, but there was an efflux of lipid-bound drug from these resistant tumors by 24 hr.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体efflux pump
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研究领域——
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适应症——
化学信息
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CAS Number70-09-7
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分子量486.95
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分子式C26H23ClN6O2
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纯度>98% (HPLC)
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溶解度DMSO:4.5 mg/mL?(9.24 mM;?Need ultrasonic)
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SMILESClc1cc(ccc1C(=O)Nc1ccc(cc1)C1=NCCN1)C(=O)Nc1ccc(cc1)C1=NCCN1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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2-Hydroxychalcone B
2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxychalcone induced cytotoxicity through oxidative stress in lipid-loaded Hepg2 cells.2'-Hydroxychalcone inhibited the induction of ICAM-1, VCAM-α, tumor necrosis factor-α, and tumor necrosis factor-alpha as determined by reverse transcription-polymerase chain reaction determined by tumor necrosis factor-alpha induces steady-state transcript levels of ICAM-1, VCAM-1, and E-selectin, and therefore may interfere with the transcription of their genes.
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Isocarlinoside
Isocarlinoside, L-malic acid, trans-aconitic acid, (+)-isocitric acid , 5-O-caffeoylquinic acid, 4-O-caffeoylquinic acid, 2"-O-rhamnosylisoorientin, and 7-O-(2"-O-glucuronosyl)glucuronosyltricin showed high antifeeding activity against brown planthopper only when they were combined.
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Delphinidin-3-O-gala...
Delphinidin-3-O-galactoside chloride has anti-obesity and hypolipidemic effects. Delphinidin-3-O-galactoside (D3G) is a water-soluble anthocyanin with antioxidant activity.
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