Okanin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Okanin 对亚油酸过氧化抑制和 DPPH 自由基清除作用均具有显着的活性。

Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.Activity-guided fractionation of the EtOH extract of flowers of Bidens bipinnata L. have been furnished five flavonoids, sulfuretin(1), butein(2), 7,8,3?2,4?2-tetrahydroxyflavanone(3), maritimetin(4) and Okanin(5). All of the compounds showed significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. The evaluation for protective effect of isolated compounds against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 3, 4 and 5 showed significant protective effects with the EC50 values of 36.1±0.9, 23.3±0.7, 41.0±1.0 and 29.8±1.1 μM, respectively.

Okanin significantly inhibits LPS-induced TLR4 expression in BV-2 cells. Okanin inhibits the translocation of the NF-κB p65 subunit from the cytosol to the nucleus. Okanin significantly suppresses LPS-induced iNOS expression and also inhibites IL-6 and TNF-α production and mRNA expression in LPS-stimulated BV-2 cells.

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Immunology/Inflammation

TLR

TLR4|NF-κB

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484-76-4

288.3

C15H12O6

>98% (HPLC)

In Vitro:?DMSO : 16.67 mg/mL (57.83 mM)

C1=CC(=C(C=C1C=CC(=O)C2=C(C(=C(C=C2)O)O)O)O)O

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(-20℃)

With Ice Pack

≥ 2 years