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LML-134
CAS No. 1542135-76-1
LML-134 ( —— )
产品货号. M21945 CAS No. 1542135-76-1
LML-134 是组胺 3 受体 (H3R)（hH3R cAMP 和 hH3R bdg，Kis 分别为 0.3 nM 和 12 nM）的反向激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥725 | 有现货 |
|
| 10MG | ￥1140 | 有现货 |
|
| 25MG | ￥1823 | 有现货 |
|
| 50MG | ￥2558 | 有现货 |
|
| 100MG | ￥3339 | 有现货 |
|
| 200MG | ￥4491 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥778 | 有现货 |
|
生物学信息
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产品名称LML-134
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述LML-134 是组胺 3 受体 (H3R)（hH3R cAMP 和 hH3R bdg，Kis 分别为 0.3 nM 和 12 nM）的反向激动剂。
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产品描述LML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM). (In Vivo):LML134 (compound 18b) (oral; 10 mg/kg) indicates rapid oral absorption, with a Tmax of 0.5 hours, t1/2 of 1.54 hours and a fraction absorbed of 44%, as well as a rapid clearance in male Sprague-Dawley rats.LML134 (i.v.; 1 mg/kg) has t1/2 of 0.44 hours, CL of 28 mL/min/kg and the low plasma protein binding in male Sprague-Dawley rat (Fu =39.0%).
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体外实验——
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体内实验LML134 (compound 18b) (oral; 10 mg/kg) indicates rapid oral absorption, with a Tmax of 0.5 hours, t1/2 of 1.54 hours and a fraction absorbed of 44%, as well as a rapid clearance in male Sprague-Dawley rats. LML134 (i.v.; 1 mg/kg) has t1/2 of 0.44 hours, CL of 28 mL/min/kg and the low plasma protein binding in male Sprague-Dawley rat (Fu =39.0%).
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同义词——
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通路GPCR/G Protein
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靶点Histamine Receptor
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受体H3 receptor
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研究领域Nervous system
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适应症Circadian Rhythm Disorders
化学信息
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CAS Number1542135-76-1
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分子量375.47
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分子式C19H29N5O3
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纯度>98% (HPLC)
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溶解度DMSO:7.5 mg/ml(19.97 mM; Need ultrasonic)
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SMILESCn1nc(ccc1=O)N1CCC(CC1)OC(=O)N1CCN(CC1)C1CCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Troxler T, et al. The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders. ChemMedChem. 2019 Jul 3;14(13):1238-1247.
产品手册
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