Levocetirizine ( Levocetirizine | Xarlin | Xusal )

产品货号. M11207 CAS No. 130018-77-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Levocetirizine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Levocetirizine 是一种 Histamine-1 Receptor Antagonist。左西替利嗪的作用机制是作为组胺 H1 受体拮抗剂。
产品描述

Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist. (In Vivo):Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t, AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats.
体外实验

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体内实验

Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t , AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats. Animal Model:30 male Sprague-Dawley rats (8 weeks old; 200-250 g) Dosage:0.4 mg/kg Administration:Oral administration (Pharmacokinetic Analysis)Result:The Cmax, AUC0-t , AUC0-∞ and t1/2 were 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively.
同义词

Levocetirizine | Xarlin | Xusal
通路

GPCR/G Protein
靶点

Histamine Receptor
受体

H1 receptor
研究领域

——
适应症

——

CAS Number

130018-77-8
分子量

388.89
分子式

C21H25ClN2O3
纯度

>98% (HPLC)
溶解度

Soluble in DMSO
SMILES

OC(=O)COCCN1CCN(CC1)[C@H](c2ccccc2)c3ccc(Cl)cc3
化学全称

Acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-

1.Pasquali M, et al. Clin Exp Allergy. 2006 Sep;36(9):1161-7.

计算器

产品手册

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