Epiberberine (chloride) ( Epiberberine chloride )

产品货号. M21543 CAS No. 889665-86-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

Epiberberine (chloride)
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Epiberberine氯化物是一种从黄连中分离出来的生物碱，是一种有效的AChE和BChE抑制剂，以及非竞争性BACE1抑制剂（IC50：1.07、6.03和8.55 μM）。
产品描述

Epiberberine chloride is an alkaloid isolated from Coptis chinensis acts as a potent AChE and BChE inhibitor and a non-competitive BACE1 inhibitor (IC50s: 1.07 6.03 and 8.55 μM).
体外实验

Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes, with an IC50 of 52.8 μM. Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation.Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner.
体内实验

Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, and urinary output of KK-Ay mice.
同义词

Epiberberine chloride
通路

Endocrinology/Hormones
靶点

AChR
受体

AChE| BChE| BACE1
研究领域

——
适应症

——

CAS Number

889665-86-5
分子量

371.8
分子式

C20H18ClNO4
纯度

>98% (HPLC)
溶解度

DMSO:7.4 mg/mL (19.9 mM)
SMILES

COC1=C(C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(C4=C3)OCO5)OC.[Cl-]
化学全称

89-Dimethoxy-1112-dihydro-[13]dioxolo[45-h]isoquinolino[21-b]isoquinolin-13-ium chloride

1.Jung HA et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009 Aug;32(8):1433-8.

计算器

产品手册

关联产品

Pancuronium bromide

Pancurium dibromide 是一种竞争性 AChR 拮抗剂 (IC50 = 5.5 nM)，可作为骨骼肌松弛剂。
Lercanidipine hydroc...

乐卡地平是二氢吡啶类钙通道阻滞剂。
(-)-(S)-B-973B

(-)-(S)-B-973B 是一种有效的变构激动剂和 α7 nAChR 的正变构调节剂。