A 582941 HCl (848591-90-2(free base))

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

A-582941 是一种具有广谱认知增强特性的 α7 神经元烟碱受体激动剂。A-582941 被发现对 α7 nAChR 表现出高亲和力结合和部分激动作用，具有可接受的药代动力学特性和出色的中枢神经系统 (CNS) 分布。

A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing propertiesA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function.?

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Endocrinology/Hormones

AChR

α7 nAChR

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316.83

C17H21ClN4

>98% (HPLC)

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Cl.CN1C[C@H]2CN(C[C@H]2C1)c3ccc(nn3)c4ccccc4

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(-20℃)

With Ice Pack

≥ 2 years