Eudesmin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Eudesmin具有抗炎、神经生长、抗惊厥和镇静作用，其作用机制可能与上调GABAA和GAD65的表达，抗脑内神经元凋亡有关。50μM(+)-eudesmin可诱导神经突生长，并抑制神经元的生长。通过刺激上游 MAPK、PKC 和 PKA 途径，增强 PC12 细胞神经生长因子 (NGF) 介导的神经突生长。

Eudesmin shows antiinflammatory neuritogenic anticonvulsant and sedative effects the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions and anti-apoptosis of neuron the in brain.50 microM (+)-eudesmin can induce neurite outgrowth and enhance nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells by stimulating up-stream MAPK PKC and PKA pathways.

Treatment of mesenchymal stem cells (MSCs) with Eudesmin (20, 40, and 80μM) disturbs adipogenesis via suppression of S6K1 signaling pathway. Eudesmin treatment inhibits activation and nuclear translocation of S6K1. S6K1-mediated phosphorylation of H2B at serine 36 (H2BS36p) is reduced upon Eudesmin treatment.

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MAPK/ERK Signaling

p38 MAPK

MAPK

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526-06-7

386.4

C22H26O6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (258.77 mM)

COc(ccc([C@@H]1OC[C@H]2[C@H](c(cc3)cc(OC)c3OC)OC[C@@H]12)c1)c1OC

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(-20℃)

With Ice Pack

≥ 2 years