021-51111890
购物车（）
sales@molnova.cn
Cardiogenol C hydrochloride(b)
CAS No. 1049741-55-0
Cardiogenol C hydrochloride(b) ( Cardiogenol C | Cardiogenol C HCl )
产品货号. M21118 CAS No. 1049741-55-0
Cardiogenol C 盐酸盐可以诱导 ESC 分化为心肌细胞 (EC50= 100 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥283 | 有现货 |
|
| 10MG | ￥466 | 有现货 |
|
| 25MG | ￥930 | 有现货 |
|
| 50MG | ￥1655 | 有现货 |
|
| 100MG | ￥2412 | 有现货 |
|
| 200MG | ￥3393 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥312 | 有现货 |
|
生物学信息
-
产品名称Cardiogenol C hydrochloride(b)
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Cardiogenol C 盐酸盐可以诱导 ESC 分化为心肌细胞 (EC50= 100 nM)。
-
产品描述Cardiogenol C hydrochloride can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
-
体外实验Cardiogenol C hydrochloride (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF,?nppa) in P19 cells when it compares to untreated control cells.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells.Cardiogenol C hydrochloride (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells.Cardiogenol C hydrochloride (1 μM; 35 days) addition from day 0 significantly increases myocardial differentiation and results in a significantly increased percentage of CBs with beating cardiomyocytes. This small moleculepromotes the development of beating cardiomyocytes in cardiovascular progenitor cell-derived cardiac bodies.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells. RT-PCR Cell Line:C2C12 cells Concentration:0.01 μM; 0.1 μM; 1 μM; 3 μM; 10 μM; 30 μM; 100 μM Incubation Time:7 days Result:Increased ANF and NKX2.5 mRNA level as a dose-dependent manner. Western Blot Analysis Cell Line:C2C12 cells Concentration:0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM Incubation Time:7 days Result:Increased cardiac Nav1.5 sodium channel protein levels.Cell Proliferation Assay Cell Line:C2C12 cells Concentration:0.01 μM; 0.1 μM; 1 μM Incubation Time:7 days Result:Did not exert toxic effects on C2C12 cells at 0.01-10 μM treatment.
-
体内实验——
-
同义词Cardiogenol C | Cardiogenol C HCl
-
通路Wnt/Notch/Hedgehog
-
靶点Wnt/beta/catenin
-
受体Wnt
-
研究领域——
-
适应症——
化学信息
-
CAS Number1049741-55-0
-
分子量296.75
-
分子式C13H17ClN4O2
-
纯度>98% (HPLC)
-
溶解度DMSO:59 mg/mL (198.82 mM)H2O:2 mg/mL (6.74 mM; Need ultrasonic)
-
SMILESCOc1ccc(Nc2nccc(NCCO)n2)cc1.Cl
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Yau Winifred WY Tang Mei-Kuen Chen Elveet al. Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells[J]. Proteome Science 9(1):3.
