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JW 67
CAS No. 442644-28-2
JW 67 ( JW67 )
产品货号. M27642 CAS No. 442644-28-2
JW 67 是经典 Wnt 通路信号传导的抑制剂。 JW 67 迅速减少活性 β-连环蛋白，随后下调 Wnt 靶基因，包括 AXIN2、SP5 和 NKD1。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥847 | 有现货 |
|
| 10MG | ￥1311 | 有现货 |
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| 25MG | ￥2678 | 有现货 |
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| 50MG | ￥4064 | 有现货 |
|
| 100MG | ￥5607 | 有现货 |
|
| 200MG | ￥7704 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥749 | 有现货 |
|
生物学信息
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产品名称JW 67
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述JW 67 是经典 Wnt 通路信号传导的抑制剂。 JW 67 迅速减少活性 β-连环蛋白，随后下调 Wnt 靶基因，包括 AXIN2、SP5 和 NKD1。
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产品描述JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.(In Vitro):JW 67 inhibits the canonical?Wnt?signaling with an?IC50?of 1.17μM. JW 67 (1 μM) increased concentration of AXIN2 and decreased the active form of β-catenin. JW 67 (10 or 25μM) reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S.
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体外实验JW67 (1 μM; 24 hours) increases concentration of AXIN2 and decreases the active form of β-catenin.JW67 affects the expression of Wnt target genes and reduces cell growth of colon cancer cell lines.JW67 shows a concentration dependent reduction in proliferation with a GI50 value of 7.8 μM. Western Blot Analysis Cell Line:SW480 cells Concentration:1 μM Incubation Time:24 hours Result:Increased the AXIN2 expression.RT-PCR Cell Line:SW480 cells Concentration:10 or 25μM Incubation Time:72 hours Result:Reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S.
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体内实验——
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同义词JW67
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通路Wnt/Notch/Hedgehog
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靶点Wnt/beta/catenin
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number442644-28-2
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分子量394.383
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分子式C21H18N2O6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 50 mg/mL (126.78 mM)
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SMILESO=C1Nc2ccccc2C11OCC2(CO1)COC1(OC2)C(=O)Nc2ccccc12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ong AM, et al. A 51-item calcium-focused food frequency questionnaire is a reliable tool to assess dietary calcium intake in postmenopausal women. Nutr Res. 2017 Jul;43:33-42.
