4-Methylbenzylidene camphor

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

4-Methylbenzylidene camphor (4-MBC) 是一种内分泌干扰物，可产生类似雌激素的作用。4-Methylbenzylidene camphor 可降低人滋养层细胞的增殖并诱导细胞凋亡。4-Methylbenzylidene camphor 激活 PI3K/AKT 和 ERK1/2 信号通路并提高细胞内 ROS 的产生。4-Methylbenzylidene camphor 是一种紫外线 (UV) 过滤剂，可能会妨碍妊娠早期胎盘的正常形成。

4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations specifically UV B radiation also has estrogenic activities.

Cell Proliferation AssayCell Line:HTR8/SVneo cells Concentration:0, 5, 10, 20, 50, 100, 200, and 400 μM Incubation Time:48 hResult:Dose-dependently inhibited cell proliferation of HTR8/SVneo cell.Apoptosis Analysis Cell Line:HTR8/SVneo cells Concentration:10, 20, 50 μMIncubation Time:48 hResult:Early and late apoptotic cells was significantly increased at 20 μM and 50 μM. Cell Cycle Analysis Cell Line:HTR8/SVneo cells Concentration: 5, 10, 20, 50 μM Incubation Time:48 h Result:Gradually increased the proportion of cells in the SubG1 phase. Cell Invasion Assay Cell Line:HTR8/SVneo cells Concentration:50 μM Incubation Time:48 hResult:Revealed a significant reduction of 81.5% in invasivenes0.Western Blot Analysis Cell Line:HTR8/SVneo cells Concentration:50 μM Incubation Time:0, 5, 15, 30, 60, 120 min Result:The phosphorylation of AKT and its downstream kinase protein, P70S6K, peaked at 5 and 15 min, respectively, subsequently decreased after 30 min, and then reactivated at 120 min RT-PCR Cell Line:HTR8/SVneo cells Concentration:20, 50 μM Incubation Time:24 h Result:Significantly increased the expression of semaphorin 6 A (SEMA6 A), GPR56, integrin subunit beta 4 (ITGB4), EPHB4, neuropilin 1 (NRP1).

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4-MBC | Enzacamene

Endocrinology/Hormones

AChR

AChE

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36861-47-9

254.37

C18H22O

>98% (HPLC)

DMSO:47 mg/mL (184.77 mM)

Cc1ccc(C=C2C(=O)C3(C)CCC2C3(C)C)cc1

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(-20℃)

With Ice Pack

≥ 2 years