Neostigmine bromide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Neostigmine bromide(Prostigmin) 是一种可逆的乙酰胆碱酯酶抑制剂和副交感神经模拟物。

Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor and a parasympatho-mimetic. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It binds to the anionic site of cholinesterase. The drug blocks the active site of acetylcholinesterase so the enzyme can no longer break down the acetylcholine molecules before they reach the postsynaptic membrane receptors. This allows for the threshold to be reached so a new impulse can be triggered in the next neuron. In myasthenia gravis there are too few acetylcholine receptors so with the acetylcholinesterase blocked, acetylcholine can bind to the few receptors and trigger a muscular contraction.

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Endocrinology/Hormones

AChR

AChE

Metabolic Disease

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114-80-7

303.2

C12H19BrN2O2

>98% (HPLC)

Water: 60 mg/mL (197.88 mM)

[Br-].CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C

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(-20℃)

With Ice Pack

≥ 2 years