Furafylline ( —— )

产品货号. M20761 CAS No. 80288-49-9

Furafylline 是人细胞色素 P450 (CYP)1A2 的选择性抑制剂 (IC50 : 0.07 μM)，

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥1691	有现货
10MG	￥2556	有现货
25MG	￥4399	有现货
50MG	￥6129	有现货
100MG	￥8001	有现货
200MG	￥10620	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥1549	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Furafylline
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Furafylline 是人细胞色素 P450 (CYP)1A2 的选择性抑制剂 (IC50 : 0.07 μM)，
产品描述

Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 μM)
体外实验

——
体内实验

Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA.
同义词

——
通路

Metabolic Enzyme/Protease
靶点

P450
受体

CYP450
研究领域

——
适应症

——

化学信息

CAS Number

80288-49-9
分子量

260.25
分子式

C12H12N4O3
纯度

>98% (HPLC)
溶解度

DMSO:12.5 mg/mL (48.03 mM)
SMILES

Cc1nc2n(Cc3ccco3)c(=O)n(C)c(=O)c2[nH]1
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Sesardic D Boobis A R Murray B P et al. Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.[J]. British Journal of Clinical Pharmacology 1990 29(6):651-663.

计算器

浓度计算器

摩尔计算器

分子量计算器

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