DHBP dibromide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DHBP 二溴化物是钙释放剂和肌肉松弛抑制剂。

DHBP dibromide is calcium release and a muscle relaxant inhibitor.

DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor.

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Diheptylviologen dibromide | 11'-DI-N-HEPTYL-44'-BIPYRIDINIUM DIBRO

GPCR/G Protein

Calcium Channel

Calcium Channel

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6159-05-3

514.38

C24H38Br2N2

>98% (HPLC)

DMSO:30 mg/mL (58.32 mM)

[Br-].[Br-].CCCCCCC[n+]1ccc(cc1)-c1cc[n+](CCCCCCC)cc1

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(-20℃)

With Ice Pack

≥ 2 years