Heterophyllin B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Heterophyllin B 通过介导 PI3K/AKT/β-catenin 通路有效抑制人食管癌细胞的粘附和侵袭。

Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associated genes.

Heterophyllin B (0-200 μM; 12-48 hours) reduces cell viability in the 75, 100 and 200 μM groups, has no effect on 5, 10, 25 and 50 μM groups.Heterophyllin B (0-50 μM; 6 hours) suppresses the expression levels of p-PI3K, p-AKT and β-catenin in a dose-dependent manner in ECA-109 cells. Cell Viability Assay Cell Line:ECA-109 cells Concentration:5 μM, 10 μM, 25 μM, 50 μM, 75 μM, 100 μM and 200 μM Incubation Time:12, 24 and 48 hours Result:Decreased cell viability at high concentrations.Western Blot Analysis Cell Line:ECA-109 cells Concentration:0 μM, 10 μM, 25 μM, 50 μM Incubation Time:6 hours Result:Decreased the phosphorylation of PI3K/AKT and the expression of β-catenin.

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GPCR/G Protein

Calcium Channel

Others

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145459-19-4

778.95

C40H58N8O8

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (128.38 mM)

CCC(C)C1C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)N2CCCC2C(=O)N3CCCC3C(=O)N4CCCC4C(=O)N1)CC(C)C)CC5=CC=CC=C5

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(-20℃)

With Ice Pack

≥ 2 years