021-51111890
购物车（）
sales@molnova.cn
Ralfinamide
CAS No. 133865-88-0
Ralfinamide ( FCE-26742A | Priralfinamide )
产品货号. M20711 CAS No. 133865-88-0
Ralfinamide 是一种口服钠通道阻滞剂，用于治疗神经性疼痛和其他疼痛病症。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥110 | 有现货 |
|
| 5MG | ￥185 | 有现货 |
|
| 10MG | ￥297 | 有现货 |
|
| 25MG | ￥598 | 有现货 |
|
| 50MG | ￥1107 | 有现货 |
|
| 100MG | ￥1611 | 有现货 |
|
| 200MG | ￥2142 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥328 | 有现货 |
|
生物学信息
-
产品名称Ralfinamide
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Ralfinamide 是一种口服钠通道阻滞剂，用于治疗神经性疼痛和其他疼痛病症。
-
产品描述Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.(In Vivo):Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain.
-
体外实验——
-
体内实验Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain. Animal Model:81 adult male Sprague–Dawley male rats (260–460 g)Dosage:80 mg/kg (7 days preoperatively), 30 mg/kg, 60 mg/kg (postoperative)Administration:Oral gavage; twice daily; until postoperative day 42Result:Suppressed neuropathic pain.
-
同义词FCE-26742A | Priralfinamide
-
通路Membrane Transporter/Ion Channel
-
靶点Sodium Channel
-
受体Na-channel
-
研究领域Neurological Disease
-
适应症Neuropathic pain
化学信息
-
CAS Number133865-88-0
-
分子量302.34
-
分子式C17H19FN2O2
-
纯度>98% (HPLC)
-
溶解度DMSO:125 mg/mL (413.44 mM)
-
SMILESC[C@H](NCc1ccc(OCc2ccccc2F)cc1)C(N)=O
-
化学全称(2S)-2-(4-(2-Fluorobenzyloxy)benzylamino)propanamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Liang X Yu G Su R . Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain[J]. European journal of pharmacology 2018 823:27-34.
产品手册
关联产品
-
AZD 7009 B
AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM. AZD 7009 inhibited late sodium current in isolated rabbit atrial and ventricular myocytes, and prolonged E-4031-induced action potential duration, promoting early post-depolarization of Purkinye fibers (EADs).
-
Pilsicainide HCl
Pilsicainide HCl 是一种纯钠通道阻滞剂。
-
PF-05089771
PF-05089771 是一种有效的、状态依赖性、亚型选择性 Nav1.7 抑制剂，IC50 为 11 nM。
