SPX-101 ( SPX101 | SPX 101 )

产品货号. M13538 CAS No. 2219362-20-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SPX-101
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SPX-101 是上皮钠通道 (ENaC) 内化的特异性肽模拟启动子。
产品描述

SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits; promotes durable reduction of ENaC membrane concentration, increases mucus transport in the β-ENaC mouse model as well as the sheep model of CF.Fibrosis Phase 2 Clinical.
体外实验

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体内实验

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同义词

SPX101 | SPX 101
通路

Membrane Transporter/Ion Channel
靶点

Sodium Channel
受体

Sodium Channel
研究领域

Other Indications
适应症

Fibrosis

1. Scott DW, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):734-744. 2. Lennox A, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):671-672.

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