[Leu5]-Enkephalin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

[Leu5]-脑啡肽是一种参与伤害感受的内源性神经肽，也是 δ-阿片受体和 μ-阿片受体的激动剂（Kis 分别为 4.0 和 3.4 nM）。

[Leu5]-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM respectively).

Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas.Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain.

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Leu-enkephalin | Leucine enkephalin | Leucyl-enkephalin

Endocrinology/Hormones

Opioid Receptor

Opioid Receptor

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58822-25-6

555.62

C28H37N5O7

>98% (HPLC)

DMSO:150 mg/mL (269.97 mM)

CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O

L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucine

(-20℃)

With Ice Pack

≥ 2 years