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[Leu5]-Enkephalin
CAS No. 58822-25-6
[Leu5]-Enkephalin ( Leu-enkephalin | Leucine enkephalin | Leucyl-enkephalin )
产品货号. M20688 CAS No. 58822-25-6
[Leu5]-脑啡肽是一种参与伤害感受的内源性神经肽，也是 δ-阿片受体和 μ-阿片受体的激动剂（Kis 分别为 4.0 和 3.4 nM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥235 | 有现货 |
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| 10MG | ￥392 | 有现货 |
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| 25MG | ￥732 | 有现货 |
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| 50MG | ￥1088 | 有现货 |
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| 100MG | ￥1485 | 有现货 |
|
| 500MG | ￥3573 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称[Leu5]-Enkephalin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述[Leu5]-脑啡肽是一种参与伤害感受的内源性神经肽，也是 δ-阿片受体和 μ-阿片受体的激动剂（Kis 分别为 4.0 和 3.4 nM）。
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产品描述[Leu5]-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM respectively).
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体外实验Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas.Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain.
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体内实验——
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同义词Leu-enkephalin | Leucine enkephalin | Leucyl-enkephalin
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通路Endocrinology/Hormones
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靶点Opioid Receptor
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受体Opioid Receptor
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研究领域——
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适应症——
化学信息
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CAS Number58822-25-6
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分子量555.62
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分子式C28H37N5O7
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纯度>98% (HPLC)
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溶解度DMSO:150 mg/mL (269.97 mM)
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SMILESCC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
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化学全称L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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UFP-101
Potent, selective and competitive silent antagonist for the NOP opioid receptor. Binds to NOP with high affinity (pKi = 10.24) and displays > 3000-fold selectivity over δ, μ and κ opioid receptors. Antinociceptive and opposes the action of nociceptin in vivo.
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Ac-RYYRWK-NH2
Potent, selective partial agonist peptide for the NOP receptor (Ki = 0.71 nM). Selective over μ, δ and κ opioid receptors (IC50 > 4000 nM). Increases food intake in vivo.
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Samidorphan HCl
Samidorphan HCl is an orally active and highly potent modulator of the opioid system that binds to μ‐opioid, κ‐opioid, and delta-opioid receptors. Samidorphan HCl is a novel μ-opioid receptor antagonist, a partial agonist for k-opioid and delta-opioid receptors. Samidorphan HCl can be used to prevent and treat schizophrenia.
