Galanthaminone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

加兰他敏酮是一种胆碱酯酶 (AChE) 抑制剂，用于治疗轻度至中度阿尔茨海默病和各种其他记忆障碍。

Galanthaminone is a cholinesterase (AChE) inhibitor?is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release.

Absorption of Galanthaminone is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.

(-)-Narwedine | Narwedin

Endocrinology/Hormones

AChR

AChE

——

——

510-77-0

285.34

C17H19NO3

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (35.05 mM)

[H][C@]12CC(=O)C=C[C@]11CCN(C)Cc3ccc(OC)c(O2)c13

(4aS8aS)-4a59101112-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a32-ef][2]benzazepin-6-one

(-20℃)

With Ice Pack

≥ 2 years