Sinapine thiocyanate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

硫氰酸芥子碱 (Sinapine Thiocyanate) 是芥子碱 (S486605) 的衍生物，芥子碱是一种存在于黑芥菜籽中的生物碱胺。它是芥子酸的胆碱酯（S486800）。

Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-oxidants and acetylcholinesterase inhibitors, that can be used for the treatment of Alzheimer’s disease (AD).

Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes.Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity.Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease.Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2.

Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota.

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Endocrinology/Hormones

AChR

Others

Others-Field

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7431-77-8

368.45

C16H24NO5·CNS

>98% (HPLC)

DMSO : ≥ 125 mg/mL; 339.26 mM

C[N+](C)(C)CCOC(=O)/C=C/c1cc(c(cc1OC)O)OC.C(#N)[S-]

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(-20℃)

With Ice Pack

≥ 2 years