Treprostinil diethanolamine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Treprostinil diethanolamine (UT-15C) 是一种有效的 EP2、DP1 和 IP 激动剂，对 EP2、DP1、IP、EP1、EP4、EP3 和 FP 的 Ki 值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinildiethanolamine 增加 cAMP 的上调，从而维持血管系统内的动态平衡。Treprostinil diethanolamine 可导致人肺动脉的血管扩张。

Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries.

Treprostinil diethanolamine (UT-15C; 0.001-10,000 nM; 60 min; HEK293 cells) has high potency in activating DP1 and EP2 receptors as well as the IP receptor with EC50 values of 0.6 nM, 6.2 nM and 1.9 nM, respectively, 36-fold less active at the EP3 receptor, 95-fold less active at the EP4 and 150-fold less active at the EP1 site than at the IP receptor.Treprostinil diethanolamine (10 μM) increases cAMP accumulation in murine and human hematopoietic stem and progenitor cells (HSPCs) .Treprostinil diethanolamine (10 μM; 2-6 h; PC3 cells) enhances the action of SDF-1 via CXCR4.

Treprostinil diethanolamine (UT-15C; 0.15 mg/kg; i.h.; every 8 h; for 10 d; BALB/c mice) enhances the ability of HSPCs to repopulate the bone marrow and increases bone marrow reconstitution.Treprostinil diethanolamine (0.15 mg/kg; i.h.; every 8 h; for 10 d; BALB/c mice) increases survival of lethally irradiated recipient mice.Treprostinil diethanolamine (0.1 mg/kg; i.h.; for 24h; male lewis rats) inhibits the mRNA expression of TNF-α and IFN-γ and increases in IL-10 expression.Animal Model:BALB/c mice Dosage:0.15 mg/kg Administration:Subcutaneous injection; every 8 hours; for 10 days Result:Increased survival of lethally irradiated recipient mice.Animal Model:Male lewis rats Dosage:0.1 mg/kg Administration:Subcutaneous injection; for 24 hours Result:Decreased the mRNA expression of TNF-α and IFN-γ and increased the expression of IL-10.

——

GPCR/G Protein

Prostaglandin Receptor

Prostaglandin Receptor

——

——

830354-48-8

495.65

C27H45NO7

>98% (HPLC)

——

N(CCO)CCO.C(C[C@H](CCCCC)O)[C@@H]1[C@@]2([C@@](CC=3C(C2)=CC=CC3OCC(O)=O)(C[C@H]1O)[H])[H]

——

(-20℃)

With Ice Pack

≥ 2 years