3-(Methylthio)propionic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3-甲硫基丙酸是蛋氨酸（尤其是 D-蛋氨酸）的代谢物之一。林肯链霉菌培养物积累的 3-甲基硫代丙烯酸的量与培养基中甲硫氨酸的浓度直接相关。该途径中的第一个中间体可能是酮酸，然后将其氧化脱羧成3-甲硫基丙酸。

3-methylthiopropionate is one of the metabolites of methionine (especially of D-methionine). Cultures of Streptomyces lincolnensis accumulated 3-methylthioacrylic acid in amounts directly related to the concentration of methionine in the medium. The first intermediate in the pathway may be the keto acid which is then oxidatively decarboxylated to 3-methylthiopropionic acid.

Methionine has consistently been shown to be the most toxic amino acid in experiments devised to assess the relative toxicity of dietary amino acids. 3-methylthiopropionate is an intermediate in methionine catabolism in rat and monkey liver in vitro. This pathway appears to account for a major portion of methionine oxidation in vitro. Cultures of Streptomyces lincolnensis accumulated 3-methylthioacrylic acid in amounts directly related to the concentration of methionine in the medium. The first intermediate in the pathway may be the keto acid, which is then oxidatively decarboxylated to 3-methylthiopropionic acid. The purified 3-MTPA has antifungal activity in assays using F. oxysporum as a model fungus. Daily measurements of shoot and root length shows severe inhibition of seed germination and root and shoot development at concentrations above 12mg for partially purified extracts. 3-methylthiopropionic acid ethyl ester possesses potential anticarcinogenic properties by inducing differentiation in well-differentiated colon cancer cells. Treatment of RCM-1 cells for 4 days with 3-methylthiopropionic acid ethyl ester between the doses of 0.25 and 2 mM progressively increases the percent area occupied by duct structures relative to the control, and also induces an increase in the number and the maximum diameter of the ducts in each culture plate.

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3-Methylsulfanylpropionic acid | 3-Methylthiopropionate | 4-Thiapentanoic acid

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646-01-5

120.17

C4H8O2S

>98% (HPLC)

H2O:25 mg/mL (208.04 mM; Need ultrasonic)

CSCCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years