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JMV 2959
CAS No. 925238-89-7
JMV 2959 ( JMV2959 | JMV 2959 | JMV-2959 )
产品货号. M19379 CAS No. 925238-89-7
JMV 2959 是一种生长激素促分泌素受体 1a 型 (GHS-R1a) 拮抗剂，IC50 为 32 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥610 | 有现货 |
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| 5MG | ￥1026 | 有现货 |
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| 25MG | ￥3980 | 有现货 |
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| 50MG | ￥5180 | 有现货 |
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| 100MG | ￥8055 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1283 | 有现货 |
|
生物学信息
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产品名称JMV 2959
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述JMV 2959 是一种生长激素促分泌素受体 1a 型 (GHS-R1a) 拮抗剂，IC50 为 32 nM。
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产品描述JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM.(In Vitro):JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM. JMV 2959 does not induce any intracellular calcium mobilization by itself.(In Vivo):When administered alone, it does not increase food intake and does not significantly stimulate growth hormone (GH) release. JMV 2959 dose dependently decreases the startle response (F(3.42)=4.4, p<0.01) and increases %prepulse inhibition (PPI) (F(3.42)=3.9, p<0.05) in the prepulse inhibition paradigm. The alteration in the startle response is mainly due to a 27% decrease in the startle seen in the highest dose of JMV 2959 (6 mg/kg) compare to vehicle (p<0.05). 6 mg/kg JMV 2959 induces a significant suppression of locomotion on days 1 to 7 relative to baseline day 0 (F(7,49)=2.21, p<0.05). Results also reveal a significant interaction between JMV 2959 treatment and day (F(1,14)=4.397, p<0.05).
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体外实验——
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体内实验——
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同义词JMV2959 | JMV 2959 | JMV-2959
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通路GPCR/G Protein
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靶点GHSR
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受体IC50: 32 nM (GHS-R1a)
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研究领域——
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适应症——
化学信息
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CAS Number925238-89-7
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分子量508.61
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分子式C??H??N?O?
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纯度>98% (HPLC)
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溶解度Soluble in DMSO
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SMILESO=C(N[C@@H](C1=NN=C(CCC2=CC=CC=C2)N1CC3=CC=C(OC)C=C3)CC4=CNC5=C4C=CC=C5)CN
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化学全称N-[(R)-1-[4-(4-Methoxybenzyl)-5-phenethyl-4H-124-triazol-3-yl]-2-(1H-indol-3-yl)ethyl]-2-aminoacetamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Moulin A et al. The 124-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959 a potent antagonist. Amino Acids. 2013 Feb;44(2):301-14.
2. Engel JA et al. Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist phencyclidine-induced impairments in prepulse inhibition. Psychopharmacology (Berl). 2015 Dec;232(23):4285-92.
3. Clifford PS et al. Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors. Addict Biol. 2012 Nov;17(6):956-63.
产品手册
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