Capromorelin Tartrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Capromorelin Tartrate 是一种有效的口服活性生长激素促分泌素受体 (GHSR) 激动剂（Ki：对于 hGHS-R1a 为 7 nM）。

Capromorelin Tartrate is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a).(In Vitro):Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM.(In Vivo):Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv.

Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM.

Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv.

CP 424391-18

GPCR/G Protein

GHSR

hGHS-R1a

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193273-69-7

655.7

C32H40N5O10

>98% (HPLC)

DMSO:100 mg/mL (152.51 mM)

O=C([C@@H]([C@@H](O)C(O)=O)O)O.CC(C)(N)C(N[C@H](COCC1=CC=CC=C1)C(N(C[C@]23CC4=CC=CC=C4)CCC2=NN(C)C3=O)=O)=O

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(-20℃)

With Ice Pack

≥ 2 years