Sulconazole Nitrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

硝酸磺康唑是磺康唑的硝酸盐形式，磺康唑是一种具有抗真菌特性的合成咪唑衍生物。

Sulconazole Nitrate is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, sulconazole nitrate seems to interfere with the autolytic degradation of fungal DNA and RNA.(In Vitro):Sulconazole mononitrate possesses a broad spectrum of antifungal activity, inhibiting the growth of dermatophytes, yeasts and various filamentous and dimorphic fungi at oncentrations below 5 mg/L in vitro. Sulconazole mononitrate has also demonstrated antibacterial activity in vitro, with MIC values below 12.5 mg/L, against several Staphylococcus species, Streptococcus faecalis and certain gram-positive anaerobes.

Sulconazole mononitrate possesses a broad spectrum of antifungal activity, inhibiting the growth of dermatophytes, yeasts and various filamentous and dimorphic fungi at oncentrations below 5 mg/L in vitro.Sulconazole mononitrate has also demonstrated antibacterial activity in vitro, with MIC values below 12.5 mg/L, against several Staphylococcus species, Streptococcus faecalis and certain gram-positive anaerobes.

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Endocrinology/Hormones

AChR

Others

Infection

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61318-91-0

460.76

C18H15Cl3N2S·HNO3

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (271.29 mM)

c1cc(ccc1CSC(Cn1ccnc1)c1c(cc(cc1)Cl)Cl)Cl.[N+](=O)(O)[O-]

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(-20℃)

With Ice Pack

≥ 2 years