Oxybutynin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

奥昔布宁是一种抗胆碱能化合物，用于缓解泌尿和膀胱困难。

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.(In Vitro):Oxybutynin (0.1, 0.3, 1, 3, 10, 30, 100 μM; 200 ms) inhibits vascular Kv channels in a concentration-dependent manner independent of anticholinergic effect in coronary arterial smooth muscle cells.(In Vivo):Oxybutynin (27.2 mg/kg; p.o.; single) exhibits significant binding of mouse brain muscarinic receptors that about a 2-fold increase in Kd?values for specific [3H]N-methylscopolamine binding 0.5 and 2 h later.

Oxybutynin (0.1, 0.3, 1, 3, 10, 30, 100 μM; 200 ms) inhibits vascular Kv channels in a concentration-dependent manner independent of anticholinergic effect in coronary arterial smooth muscle cells. Cell Viability Assay Cell Line:Coronary arterial smooth muscle cells (from male New Zealand White rabbits)Concentration:10 μM Incubation Time:200 ms Result:Rapidly inhibited the Kv current within 2 min and reduced the Kv current by 44% at +60 Mv.Inhibited the Kv current by changing the gating properties of Kv channels.Cell Viability Assay Cell Line:Coronary arterial smooth muscle cells (from male New Zealand White rabbits) Concentration:0.1, 0.3, 1, 3, 10, 30, 100 μM Incubation Time:200 ms Result:Reduced the Kv current amplitude in a concentration-dependent manner, with an IC50 value of 11.51 μM.

Oxybutynin (27.2 mg/kg; p.o.; single) exhibits significant binding of mouse brain muscarinic receptors that about a 2-fold increase in Kd values for specific [3H]N-methylscopolamine binding 0.5 and 2 h later. Animal Model:Male ddY strain mice (9 to 13-week-old).Dosage:27.2 mg/kg (76.1 μmol/kg) Administration:Oral administration; single.Result:Significant increased Kd values for specific [3H]NMS binding in mouse bladder with values of 54.7% and 40.6% when at 0.5 and 2 hours, respectively.Significant increased Kd values for specific [3H]NMS binding in mouse cerebral cortex with values of 120% and 71.2% when at 0.5 and 2 hours, respectively.

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Endocrinology/Hormones

AChR

mAChR

Neurological Disease

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5633-20-5

357.49

C22H31NO3

>98% (HPLC)

Ethanol: 71 mg/mL (198.6 mM); DMSO: 71 mg/mL (198.6 mM)

CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)C1=CC=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years