Fargesin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Fargesin 作为一种潜在的 β1AR 拮抗剂，通过 cAMP/PKA 途径可以保护大鼠免受心肌缺血/再灌注损伤。

Fargesin is a lignan from Magnolia fargesii, an oriental medicine used in the treatment of nasal congestion and sinusitis. Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-?B. Fargesin as a potential β? adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis.(In Vitro):Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-?B.Fargesin as a potential β? adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis.(In Vivo):Fargesin has antihypertensive effect in 2K1C hypertensive rats via inhibiting oxidative stress and promoting NO release.

Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-?B. Fargesin as a potential β? adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis.

Fargesin has antihypertensive effect in 2K1C hypertensive rats via inhibiting oxidative stress and promoting NO release.

Fargesin

Angiogenesis

VEGFR

β1-adrenergic receptor

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31008-19-2

370.4

C21H22O6

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (337.47 mM)

COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC5=C(C=C4)OCO5)OC

1H,3H-Furo(3,4-C)furan, 1alpha-(3,4-dimethoxyphenyl)-3abeta,4,6,6abeta-tetrahydro-4beta-((3,4-methylenedioxy)phenyl)-

(-20℃)

With Ice Pack

≥ 2 years