Boc-Asp(OMe)-fluoromethyl ketone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Boc-Asp(OME)-Fluoromethyl Ketone 是一种广泛的 caspase 抑制剂，可抑制 Fas 介导的吞噬作用和氧化破裂抑制，但不影响 IL-8 的趋化活性。

Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.(In Vitro):Boc-Asp(OME)-Fluoromethyl Keton (100 μM; 30 minutes; Polymorphonuclear leukocytes) prevents Fas-induced and spontaneous apoptosis . Boc-Asp(OME)-Fluoromethyl Keton (20 μM; 5 hours; J774.1/JA-4 cells) significantly increases LDH release .

Boc-Asp(OME)-Fluoromethyl Keton (100 μM; 30 minutes; Polymorphonuclear leukocytes) prevents Fas-induced and spontaneous apoptosis (?CH-11). Boc-Asp(OME)-Fluoromethyl Keton (20 μM; 5 hours; J774.1/JA-4 cells) significantly increases LDH release.

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Boc-Asp(OMe)-FMK

Apoptosis

Caspase

photosynthetic electron transport chain

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187389-53-3

263.265

C11H18FNO5

>98% (HPLC)

In Vitro:?DMSO : ≥ 100 mg/mL (379.85 mM)

COC(=O)CC(NC(=O)OC(C)(C)C)C(=O)CF

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(-20℃)

With Ice Pack

≥ 2 years